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      CommentAuthorTrim
    • CommentTimeMay 1st 2019
     
    What are the side effects?
  1.  
    A hard on
    •  
      CommentAuthorTrim
    • CommentTimeMay 1st 2019
     
    And what is the side effect of that?
    •  
      CommentAuthorgoatcheez
    • CommentTimeMay 2nd 2019
     
    Getting some on the side.
    •  
      CommentAuthorTrim
    • CommentTimeMay 2nd 2019
     
    And divorced?
    •  
      CommentAuthorgoatcheez
    • CommentTimeMay 2nd 2019
     
    Side effects have side effects.
    •  
      CommentAuthorTrim
    • CommentTimeMay 2nd 2019
     
    Plus some smiles.
    •  
      CommentAuthorgoatcheez
    • CommentTimeMay 2nd 2019
     
    'n blushes.
    •  
      CommentAuthormaryyugo
    • CommentTimeMay 2nd 2019 edited
     
    This is sort of interesting but maybe should be in the scams thread.

    Cost for PDE5 inhibitor tadalafil, the active ingredient in Cialis vs actual Cialis as per the Schein medical supply catalog, comparable doses...

    Cialis, 5mg x 30 tablets ... $555.34
    Tadalafil generic, same ... $4.83

    Viagra, 100mg x 100 tablets ... $8839.99
    Sildenafil 20mg x 90 tablets ... $4.23 (note, 1/5 dose and smaller quantity not that it matters)

    The sildenafil is currently being prescribed for pulmonary hypertension and the generic is licensed only for that but off label use is legal in the US. It is available off the shelf from Schein. The Tadalafil generic is "special order" per the catalog and I don't know it's legal status or how long an order would take.

    Drug makers must be sporting huge erections over those profits if anyone is still dumb enough to buy the brand and I suspect some insurance companies and perhaps even individuals are (but I don't know). I wonder if Medicare pays for PDE5 brand name products. Too lazy to find out.
    •  
      CommentAuthormaryyugo
    • CommentTimeMay 2nd 2019 edited
     
    Also:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4114345/

    (a bit old)

    Abstract
    Altered cyclic nucleotide-mediated signaling plays a critical role in the development of cardiovascular pathology. By degrading cAMP/cGMP, the action of cyclic nucleotide PDEs is essential for controlling cyclic nucleotide-mediated signaling intensity, duration, and specificity. Altered expression, localization and action of PDEs have all been implicated in causing changes in cyclic nucleotide signaling in cardiovascular disease. Accordingly, pharmacological inhibition of PDEs has gained interest as a treatment strategy and as an area of drug development. While targeting of certain PDEs has the potential to ameliorate cardiovascular disease, inhibition of others might actually worsen it. This review will highlight recent research on the physiopathological role of cyclic nucleotide signaling, especially with regard to PDEs. While the physiological roles and biochemical properties of cardiovascular PDEs will be summarized, the primary emphasis will be pathological. Research into the potential benefits and hazards of PDE inhibition will also be discussed.
    •  
      CommentAuthormaryyugo
    • CommentTimeMay 2nd 2019 edited
     
    More recent:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758391/

    Abstract
    Phosphodiesterase type 5 (PDE5) selectively hydrolyses the second messenger cGMP into 5′‐GMP, thereby regulating its intracellular concentrations. Dysregulation of the cGMP‐dependent pathway plays a significant role in various cardiovascular diseases. Therefore, its modulation by drugs, such as PDE5 inhibitors, may represent an effective therapeutic approach. There are currently four PDE5 inhibitors available for the treatment of erectile dysfunction: sildenafil, vardenafil, tadalafil and avanafil. Sildenafil and tadalafil have also received Food and Drug Administration approval for the treatment of pulmonary arterial hypertension. This review summarizes the pharmacological aspects and clinical potential of PDE5 inhibition for the treatment of myocardial ischaemia/reperfusion injury and heart failure.


    Since Tadalafil is now also approved for pulmonary hypertension as a generic, that explains why the dramatic price decrease. For erectile dysfunction, tadalafil use is still under patent hence the gigantienormous price diff. Erection or not, the drug companies sure know how to screw the patients.
  2.  
    Isn't that because they're Yank?
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      CommentAuthorgoatcheez
    • CommentTimeAug 27th 2019 edited
     
    What if aging weren’t inevitable, but a curable disease?
    https://www.technologyreview.com/s/614080/what-if-aging-werent-inevitable-but-a-curable-disease/
    ETA
    Excerpt:

    One promising treatment is metformin. It’s a common diabetes drug that has been around for many years, but animal studies suggest it could also protect against frailty, Alzheimer’s, and cancer. Giving it to healthy people might help delay aging, but without official guidance doctors are reluctant to prescribe it that way.

    One group of researchers, including Einstein College’s Barzilai, is trying to change that. Barzilai is leading a human trial called TAME (Targeting Aging with Metformin) that plans to give the drug to people aged 65 to 80 to see if it delays problems such as cancer, dementia, stroke, and heart attacks. Although the trial has struggled to raise funding—partly because metformin is a generic drug, which reduces potential profits for drug companies—Barzilai says he and his colleagues are now ready to recruit patients and start later this year.

    Metformin is one of a broader class of drugs called mTOR inhibitors. These interfere with a cell protein involved in division and growth. By turning the protein’s activity down, scientists think they can mimic the known benefits of calorie restriction diets. These diets can make animals live longer; it’s thought that the body may respond to the lack of food by taking protective measures. Preliminary human tests suggest the drugs can boost older people’s immune systems and stop them from catching infectious bugs.
  3.  
    Then only the poor would get old and die.
    •  
      CommentAuthorTrim
    • CommentTimeAug 27th 2019
     
    So you would live forever.
    •  
      CommentAuthorAngus
    • CommentTimeAug 27th 2019
     
    You think capitalism leads to inequality. Wait until there is a treatment for death!
    •  
      CommentAuthorgoatcheez
    • CommentTimeAug 27th 2019 edited
     
    Metformin is one of the cheapest drugs on the market. I swear my doctor took me off it because he gets a kickback for
    Actos scripts. (see ETA)
  4.  
    If you ask me, Kurzweil is looking pretty rough these days.
    •  
      CommentAuthorgoatcheez
    • CommentTimeAug 27th 2019 edited
     
    All he needs is some young blood.
    •  
      CommentAuthoraber0der
    • CommentTimeAug 27th 2019
     
    The only known procedure to survive death is having children. Always proven to work, ...