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      CommentAuthorAngus
    • CommentTimeMar 4th 2021
     
    That's no biggie. Conservatives have been growing hybrid Neanderthal minibrains for years.
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    https://phys.org/news/2021-03-variants-crispr-cas12a-genome.html

    - Relaxed PAM matching for extra flexibility
    - Multiplexed editing at >16 sites
    - (De)activation as well as snipping

    Impressive. Note that genes shown to correlate with IQ do not number very many (that we know of). This means that there's a possibility for a "smart shot".
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    "Our simulations showed that by destroying condensin II, you could make a human nucleus reorganize to resemble a fly nucleus
    Insect politics?

    https://phys.org/news/2021-05-biologists-periodic-table-cell-nuclei.html
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    https://singularityhub.com/2021/06/08/scientists-used-crispr-to-engineer-a-new-superbug-thats-invincible-to-all-viruses/

    Would like to find out how to create new tRNA types de novo.
    Thought the remark about compression was interesting.

    ETA Turns out tRNA is made like everything else - specified in the genome. As usual there's a ton of detail involving long barely-pronounceable chemical names (one of the reasons I didn't pursue chemistry). But here's a little gem that demonstrates how the correct tRNA anticodon gets paired with the correct amino acid. This AARS stuff is part of what Chin fucked with at Cambridge in the above paper.
    https://www.youtube.com/watch?v=nbr6SdNWxJ4
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    “This is the biggest contribution an AI system has made so far to advancing scientific knowledge. I don’t think it’s a stretch to say that,” says Demis Hassabis, co-founder and chief executive of DeepMind.

    https://www.nature.com/articles/d41586-021-02025-4
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      CommentAuthorAngus
    • CommentTimeSep 2nd 2021
     
    Hmmm...could some of our genome actually be parasitic, just using us to carry it around and make more?
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    Perhaps they're selfish!
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    https://www.nature.com/articles/d41586-021-02461-2

    Trove of CRISPR-like gene-cutting enzymes found in microbes